Clinical Resources

Published results noted below may include references to both on-label and off-label usage of the HeartLight Endoscopic Ablation System.
HeartLight X3

HeartLight X3

Pivotal Study of a Novel Motor Driven Endoscopic Ablation System.
Schmidt B, et al.
Circ EP. 2021 Feb 11;14(3):e009544. doi:10.1161/circep.120.009544.

Rapid pulmonary vein isolation utilizing the third-generation laserballoon – The PhoeniX registry
Heeger CH, Tiemeyer C, Phan HL, Meyer-Sarai R, Fink T. Tilz RR, et al.
IJC Heart & Vasculature. 2020;29:100576. doi:10.1016/j.ijcha.

Long-Term Experience

Long-Term Experience

Second-generation laser balloon ablation for the treatment of atrial fibrillation assessed by continuous rhythm monitoring: the LIGHT-AF study
Rovaris G, et al.
EP Europace. 2021. doi:10.1093/europace/euab085.

Pulmonary vein isolation using the visually guided laser balloon: a prospective, multicenter, and randomized comparison to standard radiofrequency ablation.
Dukkipati SR, Cuoco F, Kutinsky I, et al.
JACC. 2015;66(12):1350-60.

Early experiences with three types of balloon-based ablation catheters in patients with paroxysmal atrial fibrillation
Kobori A, et al.
Heart Rhythm O2. 20212(3):223-230. Doi:10.1016/j.hroo.

Visually guided laser ablation: a single-centre long-term experience.
Sediva L, Petru J, Skoda J, et al.
Europace Advance Access published July 16, 2014. doi:10.1093/europace/euu168.

Electrical isolation of pulmonary veins using laser catheter in treatment of paroxysmal and persistent atrial fibrillation. One year results.
Osca J, Andres A, Cano O, et al.
Rev Esp Cardiol. 2015. http://dx.doi.org/10.1016/j.rec.2015.08.022.

Dosing/Energy Titration

Dosing/Energy Titration

Energy titration strategies with the endoscopic ablation system: lessons from the high-dose vs. low-dose laser ablation study.
Bordignon S, Chun KRJ, Gunawardene M, et al.
Europace Advance Access published November 4, 2012. doi:10.1093/europace/eus352.

The influence of varying energy settings on efficacy and safety of endoscopic pulmonary vein isolation.
Metzner A, Wissner E, Schoonderwoerd B, et al.
Heart Rhythm. 2012;9(9):1380-1385. http://dx.doi.org/10.1016/j.hrthm.2012.03.059.

Learning Curve

Learning Curve

Cryoballoon Versus Laserballoon: Insights from the First Prospective Randomized Balloon Trial in Catheter Ablation of Atrial Fibrillation
Chun KRJ, Bordignon S, Schmidt B, et al.
Circ EP. 2021;14(2). doi:10.1161/circep.120.009294.

Second-generation visually guided laser balloon ablation system for PVI learning curve, safety and efficacy – The MERLIN REGISTRY.
Heeger CH, Phan HL, Meyer-Sarai R, Fink T, Tilz RR, et al.
Circ J. 2019 Nov 25;83(12):2443-2451.

How to learn pulmonary vein isolation with a novel ablation device: learning curve effects using the endoscopic ablation system.
Perrotta L, Bordignon S, Dugo D, Furnkranz A, Chun J, Schmidt B.
J Cardiovasc Electrophysiol. 2014;25(12):1293-1298.

Visually guided sequential pulmonary vein isolation: insights into techniques and predictors of acute success.
Schmidt B, Gunawardene M, Urban V et al.
J Cardiovasc Electrophysiol. 2012;23(6):576-582.

Review Articles

Review Articles

Endoscopic ablation systems.
Bordignon S, Chun KRJ, Gunawardene M, et al.
Expert Rev. Med. Devices. 2013;10(2):177-183.

HeartLight: The endoscopically guided laser ablation system.
Schmidt B.
Asia Pacific Heart Rhythm Society Newsletter. 2015;22:2-5.

Meta-Analysis

Meta-Analysis

Laser balloon ablation for AF: A systematic review and meta-analysis.
Reynolds M, Zheng Q, Doros G.
J Cardiovasc Electrophysiol. 2018;29(10):1363-1370.